Erectile dysfunction (ED or (male) impotence) is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis. There are various underlying causes, such as cardiovascular leakage and diabetes, many of which are medically treatable. Nerve trauma from prostatectomy surgery can cause chronic erectile dysfunction.
PDE5 Inhibitors
The cyclic nucleotide phosphodiesterases constitute a group of enzymes that catalyse the hydrolysis of the cyclic nucleotides cyclic AMP and cyclic GMP. They exist in different molecular forms and are unevenly distributed throughout the body. These multiple forms or subtypes of phosphodiesterase were initially isolated from rat brain by Uzunov and Weiss in 1972 and were soon afterwards shown to be selectively inhibited by a variety of drugs in brain and other tissues. The potential for selective phosphodisterase inhibitors to be used as therapeutic agents was predicted as early as 1977 by Weiss and Hait. This prediction has now come to pass in a variety of fields, one of which is in the pharmacological treatment of erectile dysfunction.
One of the forms of phophodiesterase is termed PDE5. The prescription PDE5 inhibitors sildenafil (Viagra®), vardenafil (Levitra®) and tadalafil (Cialis®) are prescription drugs which are taken orally. They work by blocking the action of PDE5, which causes cGMP to degrade. CGMP specific phosphodiesterase type 5 causes the smooth muscle of the arteries in the penis to relax, allowing the corpus cavernosum to fill with blood.
The causes of erectile dysfunction may be physiological or psychological. Physiologically, erection is a hydraulic mechanism based upon blood entering and being retained in the penis, and there are various ways in which this can be impeded, most of which are amenable to treatment. Psychological impotence is where erection or penetration fails due to thoughts or feelings (psychological reasons) rather than physical impossibility; this can often be helped. Notably in psychological impotence there is a very strong placebo effect.
Erectile dysfunction, tied closely as it is to cultural notions of potency, success and masculinity, can have devastating psychological consequences including feelings of shame, loss or inadequacy; often unnecessary since in most cases the matter can be helped. There is a strong culture of silence and inability to discuss the matter. In fact around 1 in 10 men will experience recurring impotence problems at some point in their lives.
Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of the first pharmacologically approved remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by heavy advertising.
For a full list of Erectile Dysfunction medications available through our service, please visit our Men’s Health and ED section.
Cialis
You can now buy prescription Cialis online through a licensed US pharmacy located in your region using your credit card, including the one issued by your HSA. In clinical trials, CIALIS was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. CIALIS has not been studied for multiple sexual attempts per dose.
Other items in this category include: Levitra, Viagra
Click any link below to complete the health questionnaire and order form or call one of our helpful customer service representatives at 1 (888) 738-3822.
| Item Name | Price | Click to Buy | |
Cialis | |||
| Cialis 20mg 10 Tablets | $239.95 | Click to Buy | |
Cialis | |||
| Cialis 20mg 15 Tablets | $299.95 | Click to Buy | |
| Cialis 20mg 20 Tablets | $369.95 | Click to Buy | |
Cialis | |||
| Cialis 20mg 3 Tablets | $109.95 | Click to Buy | |
Cialis | |||
| Cialis 20mg 30 Tablets | $519.95 | Click to Buy | |
| Cialis 20mg 5 Tablets | $159.95 | Click to Buy | |
Cialis | |||
| Cialis Daily Use 2.5 mg 30 tablets | $239.95 | Click to Buy | |
Viagra
You can now buy prescription Viagra online through a licensed US pharmacy located in your region using your credit card, including the one issued by your HSA. Viagra is taken by mouth as needed between four hours and one-half hour before sexual activity (about one hour before is most effective). Take only as directed, usually once daily as needed. Sildenafil works along with sexual stimulation to help achieve an erection.
Other items in this category include: Cialis, Levitra
Click any link below to complete the health questionnaire and order form or call one of our helpful customer service representatives at 1 (888) 738-3822.
Levitra
You can now buy prescription Levitra online through a licensed US pharmacy located in your region using your credit card, including the one issued by your HSA. Levitra is taken orally when needed between 4.30 hrs and 30 minutes before sexual activity. Take Levitra only as directed, usually once daily as needed. Levitra works along with sexual stimulation to help achieve an erection.
Other items in this category include: Cialis, Viagra
Click any link below to complete the health questionnaire and order form or call one of our helpful customer service representatives at 1 (888) 738-3822.